Origin: United States, Manufacturer: DATA SCIENCE INTERNATIONAL (formerly BUXCO brand)

Whole Body Plehysmography
The DSI Buxco Whole Body Plehysmography detection system uses Halcyon ® The patented noise reduction technology is mainly used to monitor the respiratory function of experimental animals in a state of wakefulness, free movement, non restraint, and non anesthesia. During the monitoring process, experimental animals need to be placed in specially designed chambers for experimentation. The WBP chamber is equipped with a highly sensitive pressure sensor that can detect subtle pressure changes inside the chamber. The pneotachs with sieve holes on the cavity sense the subtle pressure changes generated by the airflow inside and outside the cavity. Based on these subtle flow signals, Buxco FinePointe software provides you with professional and accurate parameters related to lung ventilation, bronchial constriction, etc. through professional derivation formulas and analysis.

Typical applications include:
Bronchoconstriction, Bronchial stenosis
Tidal Volume, tidal volume
Respiratory Rate, Respiratory rate
Airway Irritation, Airway stimulation
Dose Response, Dose-response reaction
Airway Hyperresponsiveness， Airway hyperresponsiveness

characteristic: • Animals are awake and free to move around (non-invasive testing); • Can monitor conscious and unconstrained experimental animals, which is one of the core group experiments for safety pharmacology GLP • Detect the Penh airway constriction index Pause、 Indicators such as tidal volume; • Newly added indicators related to airway inflammation research, TB and TP; Paired with Cough analyzer, cough counting can be performed to perfectly distinguish between cough and sneeze waveforms; Fully automatic calibration, avoiding the tedious work and uncertainty of manual daily calibration; The digital to analog conversion (A/D), preamplifier, atomization drug control, and bias current meter are integrated into the same controller, making the structure more compact and concise, and easy to install and rearrange; The air supply of the deflectometer can be set to 1LPM for mice or 2.5LPM for rats/guinea pigs; • Standard atomization drug delivery function; (Can be used to stimulate airway response) Suitable for rapid initial screening; Suitable for long-term follow-up research; • Port with water and food feeding for convenient long-term experiments; • Optional: Temperature/humidity monitoring to improve data accuracy; Temperature and blood pressure monitoring; • A movable control handle for easy operation; • Easy to expand. Multiple animals can be detected simultaneously through USB connection. At present, we can provide body tracing boxes for mice, rats, guinea pigs, ferrets, birds, rabbits, cats, dogs, and primates, and can customize whole body tracing boxes for specific animals.

System composition:
A typical system includes: a whole-body plethysmograph, a corresponding number of sensors, a deflectometer, an nebulization drug delivery system, a main controller with a preamplifier and USB analog-to-digital converter installed in its slot, analysis software, and related accessories. Optional system: Sensors with temperature and humidity probes can be optionally equipped to accurately measure the temperature and humidity inside the chamber during experiments, greatly improving the accuracy of parameters such as tidal volume.

12 mouse body tracing boxes

Rat body tracing box

Guinea pig body tracing box

The picture shows the FinePointe WBP system, which comes standard with 4 chambers and has high integration. It integrates previously independent systems such as atomization control and deflectors, making it more space saving than the old model.

FinePointe software generates trend charts and data tables during real-time data collection, and can search for the same time point corresponding to each other by right clicking on a row in the respiratory signal waveform, trend chart, or data table.

Available parameters:
Respiratory rate, tidal volume, minute ventilation, bronchial stenosis, apnea, exhalation shape ratio of respiratory waveform, respiratory compensation, peak inspiratory flow rate, peak expiratory flow rate, inspiratory time, expiratory time, expiratory flow rate at 50% ventilation, relaxation time, inspiratory end time, expiratory end time, degree of respiratory depression, etc

Extended measurement:

Experimental animal cough detection analysis, apnea research (please inquire for more information if needed)

Note: This product is mainly used as an experimental instrument for scientific research. Non clinical medical equipment.

Other related products:

Airway resistance and lung compliance measurement system (invasive measurement of airway resistance and lung compliance)
Animal lung function testing system (the most comprehensive animal respiratory lung function measurement system, invasive measurement)

Dual chamber plethysmography system (special airway resistance and lung compliance, non-invasive measurement)

Cigarette exposure poisoning device (COPD modeling)
Mass Dosing Aerosol Treatment System (for nebulizing drugs, allergens, or other mixtures applied to animals)